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First-in-human Study of AMG 193, an MTA-cooperative PRMT5 Inhibitor, in Patients with MTAP-deleted Solid Tumors: Results from Phase I Dose Exploration5

J. Rodon,H. Prenen,A. Sacher,M. Villalona-Calero, N. Penel, A. El Helali,S. Rottey, N. Yamamoto, F. Ghiringhelli,M. E. Goebeler, T. Doi,S. Postel-Vinay,C. -c. Lin,C. Liu, C. -h. Chuang, K. Keyvanjah, T. Eggert,B. h. o ' Neil

ANNALS OF ONCOLOGY（2024）

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Key words
MTAP,methylthioadenosine phosphorylase,non-small-cell lung cancer,pancreas cancer,PRMT5,protein arginine methyltransferase 5,synthetic lethality
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