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Modeling Suggests SARS-CoV-2 Rebound after Nirmatrelvir-Ritonavir Treatment is Driven by Target Cell Preservation Coupled with Incomplete Viral Clearance

Tin Phan,Ruy M. Ribeiro, Gregory E. Edelstein,Julie Boucau,Rockib Uddin,Caitlin Marino,May Y. Liew,Mamadou Barry,Manish C. Choudhary,Dessie Tien, Karry Su,Zahra Reynolds,Yijia Li, Shruti Sagar,Tammy D. Vyas,Yumeko Kawano,Jeffrey A. Sparks,Sarah P. Hammond,Zachary Wallace,Jatin M. Vyas,Jonathan Z. Li,Mark J. Siedner,Amy K. Barczak,Jacob E. Lemieux,Alan S. Perelson

JOURNAL OF VIROLOGY（2025）

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Key words
SARS-CoV-2,viral rebound,nirmatrelvir-ritonavir,antiviral therapy,target cell preservation,mathematical model,viral dynamics,adaptive immune response,incomplete viral clearance,treatment timing
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