Cyclin-Dependent Kinase 8 Represents a Positive Regulator of Cytomegalovirus Replication and a Novel Host Target for Antiviral Strategies

Debora Obergfaell,Markus Wild,Mona Sommerer, Malena Barillas Dahm,Jintawee Kicuntod,Julia Tillmanns, Melanie Koegler,Josephine Loesing,Kishore Dhotre,Regina Mueller,Christina Wangen,Sabrina Wagner, Quang V. Phan,Lueder Wiebusch,Katarina Briestenska,Jela Mistrikova, Lauren Kerr-Jones,Richard J. Stanton,Sebastian Voigt,Friedrich Hahn,Manfred Marschall

PHARMACEUTICS（2024）

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Key words

human pathogenic herpesviruses,virus-supportive cellular protein kinases,cyclin-dependent kinase 8 (CDK8),human cytomegalovirus (HCMV),regulation of viral replication,negative impact of CDK8 inhibitors,siRNA-mediated CDK8 knock-down,antiviral approach with CDK8-inhibitory small molecules,novel host-directed targeting strategies,broad-spectrum antiviral CDK8 inhibitors

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