Mechanism of Non-Competitive Inhibition of the SARS-CoV-2 3CL Protease Dimerization: Therapeutic and Clinical Promise of the Lichen Secondary Metabolite Perlatolinic Acid

Lorenza Fagnani,Pierangelo Bellio,Antonio Di Giulio,Lisaurora Nazzicone,Roberto Iorio,Sabrina Petricca,Nicola Franceschini,Laura Bertarini,Donatella Tondi,Giuseppe Celenza

Heliyon（2024）

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Key words

SARS-CoV-2 3CL protease inhibition,Perlatolinic acid antiviral activity,Lichen metabolites against COVID-19,3CL protease dimer interface,Broad-spectrum COVID-19 therapeutics

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