Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition Against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants.

Xu Wang,Dimitar Gotchev,Kristi Yi Fan, Marvin M. Vega,Nagraj Mani, Kayleigh McGovern-Gooch,Andrea Cuconati, Breanna Tercero,Xiaohe Wang, Philip Carpino,Klaus Maskos,Paolo A. Centrella, Andreas Schmitt, Franziska Preuss, Archna Prasad, Chia-yi Chen,Matthew A. Clark,John P. Guilinger, Shawn Johnstone, Konstanze von Konig,Anthony D. Keefe, Jenny Liu, Stephane Turcotte,Ying Zhang, Debora L. Konz Makino,Angela M. Lam,Andrew G. Cole,Michael J. Sofia

JOURNAL OF MEDICINAL CHEMISTRY（2024）

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