Structure-Activity Relationships and Discovery of (S)-5-(tert-butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1, 2,5,6-Tetrahydropyrido[2′,1′:2,3]Imidazo[4,5-h]quinoline-3-carbox Ylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer