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Somatic Recombination Between an Ancient and a Recent NOTCH2 Gene Variant is Associated with the NOTCH2 Gain-of-Function Phenotype in Chronic Lymphocytic Leukemia

Rainer Hubmann,Martin Hilgarth, Tamara Loewenstern, Andrea Lienhard, Filip Sima, Manuel Reisinger, Claudia Hobel-Kleisch,Edit Porpaczy,Torsten Haferlach,Gregor Hoermann,Franco Laccone,Christof Jungbauer,Peter Valent,Philipp B. Staber,Medhat Shehata,Ulrich Jaeger

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES（2024）

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Key words
NOTCH2,gain of function,haplotypes,somatic recombination,evolution,CLL
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