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TLR4 Downregulation Protects Against Cisplatin-Induced Ototoxicity in Adult and Pediatric Cancer Patients

John J. W. Lee,Asna Latif,Erika N. Scott, Abhinav Thakral,Mary B. Mahler,Beth Brooks,Katrina Hueniken,Astrid Billfalk-Kelly,Osvaldo Espin-Garcia,Luna Jia Zhan,S. Rod Rassekh, Lucie Pecheux,Maria Spavor, Yuling Li,David Goldstein,Andrew Hope,Colin J. Ross,Geoffrey Liu,Bruce C. Carleton,Amit P. Bhavsar

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS（2025）

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Key words
Cisplatin,Ototoxicity,Hearing loss,Pharmacogenetics,Adverse drug reaction,Toll-like receptor 4
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