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Upstream Targeting for the Prevention of Atrial Fibrillation: Targeting Risk Interventions and Metformin for Atrial Fibrillation (Trim-Af)-rationale and Study Design.

Sojin Y. Wass,John Barnard, Hyun Su Kim,Han Sun, William Telfer,Taylor Schilling, Benico Barzilai,Dennis Bruemmer,Leslie Cho,Julie Huang,Ayman Hussein,Sangeeta R. Kashyap, Luke Laffin,Reena Mehra, Chris Moravec,Walid Saliba,Prashanthan Sanders,Steven Nissen,Niraj Varma, Jonathan Smith,David Van Wagoner,Mina K. Chung

Journal of Interventional Cardiac Electrophysiology（2024）

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Key words
Atrial fibrillation,Upstream therapies,Disease progression,Metformin,Lifestyle and risk factor modification
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