Covalent Fragments Acting As Tyrosine Mimics for Mutant P53-Y220c Rescue by Nucleophilic Aromatic Substitution.

Theresa Klett,Jason Stahlecker,Simon Jaag, Benedikt Masberg,Cornelius Knappe,Michael Laemmerhofer,Murray Coles,Thilo Stehle,Frank M. Boeckler

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE（2024）

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p53 stabilizers,T-p53C-Y220C,covalent fragment-baseddrug discovery (FBDD),warheads,differential scanningfluorimetry (DSF),intact protein mass spectrometry,X-ray crystallography,fluorescence polarization assay (FPA)

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