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Investigating Residual Trace Metals in Recombinant Monoclonal Antibodies to Facilitate Drug Development with LC-UV-ICPMS-HRMS

Xueqing Zhao,Jikang Wu, Yu Zhang, Hongxia Wang,Haibo Qiu,Ning Li

ANALYTICA CHIMICA ACTA(2025)

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Key words
Trace metals,IgG mAbs,Metal speciation,Metal-mAb interactions,Native SEC,ICPMS,Nano-ESI-HRMS
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