Anticancer Plant Secondary Metabolites Evicting Linker Histone H1.2 from Chromatin Activate Type I Interferon Signaling

Olga Vlasova, Irina Antonova, Khamis Magomedova, Alena Osipova, Polina Shtompel, Anna Borunova, Tatiana Zabotina,Gennady Belitsky,Irina Budunova,Albert Jordan,Kirill Kirsanov,Marianna Yakubovskaya

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES（2025）

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Key words

plant secondary metabolites,plant polyphenols,phytochemicals,DNA-binding compounds,anticancer effects,chromatin structure,linker histone eviction,type I interferon signaling,<italic>LINE1</italic> transcription,double-stranded DNA ends

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