Empirical Antibiotic Therapy Improves Outcomes in Mechanically Ventilated Patients with COVID-19: an Emulated Targeted Trial Within a Prospective, Multicentre Cohort Study

Pedro D. Wendel-Garcia,Adrian Ceccato,Ana Motos, Diego Franch-Llasat, Mar O. Perez-Moreno, Marie F. Domenech-Spanedda, Elena Chamarro-Marti,Ricard Ferrer,Laia Fernandez-Barat,Jordi Riera, Sergio alvarez-Napagao,Oscar Penuelas, Jose A. Lorente,Raquel Almansa,Albert Gabarrus,David de Gonzalo-Calvo,Jessica Gonzalez,Jose M. Anon,Carme Barbera,Jose Barberan, Aaron Blandino-Ortiz, Elena Bustamante-Munguira, Jesus Caballero, Cristina Carbajales-Perez, Nieves Carbonell, Mercedes Catalan-Gonzalez, Patricia Barral-Segade, Rafael Manez, Mari C. de la Torre, Emili Diaz, Angel Estella, Elena Gallego, Jose L. Garcia-Garmendia, Jose Garnacho-Montero, Rosario Amaya-Villar, Jose M. Gomez, Arturo Huerta, Ruth N. Jorge-Garcia, Ana Loza-Vazquez, Judith Marin-Corral, Maria Cruz Martin-Delgado, Amalia Martinez de la Gandara, Ignacio Y. Martinez-Varela, Juan Lopez-Messa, Guillermo Muniz-Albaiceta, Mariana A. Novo, Yhivian Penasco, Juan C. Pozo-Laderas, Pilar Ricart, Angel Sanchez-Miralles, Susana Sancho, Lorenzo Socias, Jordi Sole-Violan, Fernando Suarez-Sipmann, Luis Tamayo, Jose Trenado, Ferran Barbe, Antoni Torres, Ferran Roche-Campo, CIBERESUCICOVID Investigators

JOURNAL OF INFECTION（2025）

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Key words

Prophylactic antibiotics,Bacterial superinfections,Bacterial coinfections,Ventilator-associated pneumonia,Critically ill

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