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A Triad of Somatic Mutagenesis Converges in Self-Reactive B Cells to Cause a Virus-Induced Autoimmune Disease

Clara Young,Mandeep Singh,Katherine J.L. Jackson,Matt A. Field,Timothy J. Peters,Stefano Angioletti-Uberti,Daan Frenkel,Shyamsundar Ravishankar,Money Gupta,Jing J. Wang,David Agapiou,Megan L. Faulks,Ghamdan Al-Eryani,Fabio Luciani,Tom P. Gordon,Joanne H. Reed,Mark Danta,Andrew Carr,Anthony D. Kelleher,Gregory J. Dore

Immunity（2025）

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Key words
hepatitis C virus,cryoglobulinemic vasculitis,somatic mutation,B lymphocyte,rheumatoid factor,autoantibody,antigenic mimicry,antibody affinity,superselectivity
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