Circccny Enhances Lenvatinib Sensitivity and Suppresses Immune Evasion in Hepatocellular Carcinoma by Serving As a Scaffold for SMURF1 Mediated HSP60 Degradation

Lei Yang,Wenliang Tan,Min Wang,Yingcheng Wei, Zhiqin Xie, Qingbin Wang, Ziyu Zhang, Hongkai Zhuang, Xiaowu Ma, Bingkun Wang,Jiahao Jiang,Yajin Chen,Changzhen Shang

CANCER LETTERS（2025）

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Key words

Hepatocellular carcinoma,Lenvatinib,circCCNY,Heat shock protein 60,MAPK signaling pathway

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