Optimization of a Micro-Scale Air–liquid-Interface Model of Human Proximal Airway Epithelium for Moderate Throughput Drug Screening for SARS-CoV-2

Chandani Sen,Tammy M. Rickabaugh,Arjit Vijey Jeyachandran, Constance Yuen, Maisam Ghannam,Abdo Durra, Adam Aziz, Kristen Castillo,Gustavo Garcia,Arunima Purkayastha,Brandon Han, Felix W. Boulton, Eugene Chekler, Robert Garces,Karen C. Wolff,Laura Riva,Melanie G. Kirkpatrick, Amal Gebara-Lamb,Case W. McNamara,Ulrich A. K. Betz,Vaithilingaraja Arumugaswami,Robert Damoiseaux,Brigitte N. Gomperts

Respiratory Research（2025）

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关键词

Human mucociliary epithelium,SARS-CoV-2,Respiratory viral infections,High throughput drug screening,Anti-viral screening,Small-molecules,Air–liquid-interface,Heterogeneity,Image quantification,RNA sequencing

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