Disrupting AGR2/IGF1 Paracrine and Reciprocal Signaling for Pancreatic Cancer Therapy

Hongzhen Li, Zhiheng Zhang, Zhao Shi, Siqi Zhou,Shuang Nie, Yuanyuan Yu, Lingling Zhang, Yifeng Sun, Chao Fang, Jingxiong Hu, Yiqi Niu,Kathleen Schuck,Lei Wang,Kuirong Jiang,Zipeng Lu,Christoph Kahlert,Susanne Roth,Martin Loos,Ingrid Herr, Yoshiaki Sunami

Cell Reports Medicine（2025）

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Key words

pancreatic cancer,AGR2,IGF1,immunosuppression,desmoplastic reaction,molecular targeting,IGF1R

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