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The Intestinal Microbiome and Metabolome Discern Disease Severity in Cytotoxic T-lymphocyte-associated Protein 4 Deficiency

Prabha Chandrasekaran, Máté Krausz, Yu Han,Noriko Mitsuiki,Annemarie Gabrysch, Christina Nöltner,Michele Proietti, Theo Heller,Caroline Grou, Virginie Calderon,Poorani Subramanian,Drew R. Jones, Yik Siu,Clayton Deming, Sean Conlan,Steven M. Holland,Julia A. Segre,Gulbu Uzel,Bodo Grimbacher, Emilia Liana Falcone

Microbiome（2025）

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Key words
CTLA4 deficiency,Common variable immunodeficiency,Disease severity,Microbiome,Metabolome,Dysbiosis,Gastrointestinal inflammation,Immunomodulator,Immune dysregulation,Autoimmunity,Inborn error of immunity
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