Identifying Heterogeneity of Treatment Effect for Antibiotic Duration in Bloodstream Infection: an Exploratory Post-Hoc Analysis of the BALANCE Randomised Clinical Trialresearch in Context Sean W.X. Ong , Ruxandra Pinto , Asgar Rishu , Steven Y.C. Tong , Robert J. Commons , John M. Conly , Gerald A. Evans , Michael Fralick , Christopher Kandel , Philippe R.S. Lagacé-Wiens , Todd C. Lee , Sylvain A. Lother , Derek R. MacFadden , John C. Marshall , Valérie Martel-Laferrière , Michael Mayette , Emily G. McDonald , John D. Neary , Josef Prazak , Edward Raby , Adrian Regli , Benjamin A. Rogers , Stephanie Smith , Linda R. Taggart , Han Ting Wang , Terence Wuerz , Dafna Yahav , Paul J. Young , Robert A. Fowler , Nick Daneman , Benjamin Rogers , Yahya Shehabi , Rachael Parke , Deborah J. Cook , Yaseen Arabi , John Muscedere , Steven Reynolds , Richard Hall , Dhiraj Bhatia Dwivedi , Colin McArthur , Shay McGuinness , Bryan Coburn , Anna Geagea , Pavani Das , Phillip Shin , Michael Detsky , Andrew Morris , Jeff E. Powis , Wendy Sligl , Sean M. Bagshaw , Nishma Singhal , Emilie Belley-Cote , Richard Whitlock , Kosar Khwaja , Susan Morpeth , Alex Kazemi , Tony Williams , Lauralyn McIntyre , Jennifer L.Y. Tsang , Francois Lamontagne , Alex Carignan , John Marshall , Jan O. Friedrich , Robert Cirone , Mark Downing , Christopher Graham , Joshua Davis , Erick Duan , John Neary , Gerald Evans , Basem Alraddadi , Sameera Al Johani , Claudio Martin , Sameer Elsayed , Ian Ball , François Lauzier , Alexis F. Turgeon , Henry Thomas Stelfox , John Conly , Richard Sullivan , Jennifer Grant , Ilya Kagan , Paul Young , Cassie Lawrence , Kevin O'Callaghan , Matthew Eustace , Keat Choong , Pierre Aslanian , Ulrike Buehner , Tom Havey , Alexandra Binnie , Brenda Reeve , Edward Litton , Sylvain Lother , Anand Kumar , Ryan Zarychanski , Tomer Hoffman , David L. Paterson , Peter Daley , Emmanuel Charbonney , Jean-Francois Naud , Sally Roberts , Ravindranath Tiruvoipati , Sachin Gupta , Gordon Wood , Omar Shum , Spiros Miyakis , Peter Dodek , Clement Kwok , Karen Doucette EClinicalMedicine（2025）
关键词
Bloodstream infections, Antibiotic duration, Clinical trial, Heterogeneity of treatment effect, Antimicrobial stewardship
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