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    • Transplantation direct Journal

    Papers
    Eight Weeks of Ledipasvir/Sofosbuvir in Kidney Transplant Recipients with Hepatitis C Genotype 1 Infection
    Jennifer S. Husson,Bharath Ravichandran,Srijana Jonchhe,Shyamasundaran Kottilil,Eleanor Wilson
    Transplantation Direct（2017）
    Short treatment duration of ledipasvir/sofosbuvir (LDV/SOF) has been successfully used to treat hepatitis C virus (HCV) genotype 1 infection in treatment-naive noncirrhotic patients with viral loads (VLs) under 6 million IU/mL. However, this short duration has not been studied in...
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    Lowering Perfusate Temperature from 37°C to 32°C Diminishes Function in a Porcine Model of Ex Vivo Kidney Perfusion
    Thomas D. Adams,Meeta Patel,Sarah A. Hosgood,Michael L. Nicholson
    Transplantation Direct（2017）
    BACKGROUND:Ex vivo perfusion (EVP) is a novel method of preservation. However, optimal perfusion conditions remain undetermined. Reducing the temperature of the perfusate to subnormothermia may be beneficial during EVP and improve early graft function. The aim of this study was t...
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    Selecting DCD Recipients Using Predictive Indices
    Saif Ganni,Greta Handing,Adrish Anand,Spencer Barrett,Nhu Thao Nguyen Galvan,Christine O'Mahony,John A. Goss,Ronald T. Cotton,Abbas Rana
    TRANSPLANTATION DIRECT（2023）
    Background. Donation after circulatory death (DCD) allografts might represent one of the largest untapped sources of liver allografts. Our aim was to identify independent recipient risk factors that predict mortality in DCD allograft recipients to preselect optimal candidates for...
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    A Preliminary Study into the Significance of Intrarenal Reflux in BK Virus Nephropathy after Kidney Transplantation
    Kunio Kawanishi,Kazuho Honda,Junki Koike,Motoshi Hattori,Shouhei Fuchinoue,Kazunari Tanabe,Hideaki Oda,Yoji Nagashima
    Transplantation Direct（2016）
    BACKGROUND:The BK virus typically colonizes the lower urinary tract and is the causative agent in BK virus nephropathy (BKVN), which can progress to allograft dysfunction and graft loss. Urinary reflux in kidney allografts is induced by vesicoureteral reflux or disturbances in in...
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    Organ Donation among Tiers of Health Workers: Expanding Resources to Optimize Organ Availability in a Developing Country
    Rotimi Oluyombo,Bimbo Michael Fawale,Olusegun Adesola Busari,Jeffery Olarinde Ogunmola,Timothy Olusegun Olanrewaju,Callistus Adewale Akinleye,Rufus Wale Ojewola,Musah Yusuf,Omotola Obajolowo,Michael Soje,Babajide Gbadegesin
    TRANSPLANTATION DIRECT（2016）
    The global increase in end organ failure but disproportional shortage of organ donation calls for attention. Expanding the organ pool by assessing and improving health workers' attitude at all levels of care may be a worthwhile initiative. Methods. A questionnaire-based cross sec...
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    Multivariate Analysis of Immune Reconstitution and Relapse Risk Scoring in Children Receiving Allogeneic Stem Cell Transplantation for Acute Leukemias
    Manuela Spadea,Francesco Saglio,Serena I. Tripodi,Mariacristina Menconi,Marco Zecca,Franca Fagioli
    Transplantation Direct（2021）
    Background. A timely and effective immune reconstitution after hematopoietic stem cell transplantation (HSCT) is of crucial importance to enhance graft-versus-leukemia reaction in hematological malignancies. Several factors can influence the yield of this process, and new mathema...
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    Resources Utilization after Liver Transplantation in Patients with and Without Hepatopulmonary Syndrome: Cleveland Clinic Experience
    Jacek B. Cywinski,Natalya Makarova, Andrea Arney,Qiang Liu,Masato Fujiki,K. V. Narayanan Menon,Cristiano Quintini
    Transplantation Direct（2020）
    Background. Patients with hepatopulmonary syndrome (HPS) reportedly experience posttransplant morbidity and require more resources to care during perioperative period. The exact incremental increase of resources utilization compared with non-HPS population remains unknown. Method...
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    Simultaneous Versus Sequential Heart-liver Transplantation: Ideal Strategies for Organ Allocation
    A. Justin Rucker,Kevin L. Anderson,Michael S. Mulvihill,Babatunde A. Yerokun,Andrew S. Barbas,Matthew G. Hartwig
    Transplantation Direct（2018）
    Background Simultaneous heart-liver (SHL) transplantation is an efficacious therapeutic modality for patients with combined heart and liver failure. However, the extent to which heart transplantation followed by sequential liver transplantation (LAH) can match the benefit of simu...
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    Anti-CD28 Antibody-Initiated Cytokine Storm in Canines
    Steven L. Rosinski,Rainer Storb,Roland K. Strong,George E. Sale,Diane M. Stone,Mesfin M. Gewe,Della J. Friend,V. Kraig Abrams,Julie Randolph-Habecker,Scott S. Graves
    TRANSPLANTATION DIRECT（2015）
    Background. CD28 signal blockade after T cell receptor activation is under intense investigation as a tolerance-inducing therapy for transplantation. Our goal is to produce a CD28-specific reagent as a therapy for the prevention of graft rejection and graftversus-host disease in ...
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    Lose Weight to Donate: Development of a Program to Optimize Potential Donors with Hepatic Steatosis or Obesity for Living Liver Donation
    John T. Rose,Paola Vargas,Tara Seay,Arthur J. Pesch,Tessa Williams,Anita Sites,Zachary Henry,Patrick G. Northup,Shawn J. Pelletier,Jose Oberholzer,Curtis K. Argo,Nicolas Goldaracena
    TRANSPLANTATION DIRECT（2021）
    Background. Living donor liver transplantation offers an attractive option to reduce the waitlist mortality. However, in recent years, the rising prevalence of obesity and nonalcoholic fatty liver disease has posed a serious threat to the donor pool while simultaneously increasin...
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    An Unusual Cause of Hepatitis with Nephrotic Syndrome in a Kidney Transplant Recipient
    Koon Ming Chan,Siddharth Sridhar,Wing Hung Lau,Chi Yuen Cheung
    Transplantation Direct（2022）
    INTRODUCTION Hepatitis E virus (HEV) infection is an emerging cause of viral hepatitis worldwide. HEV belongs to the family Hepeviridae, which includes 2 genera, namely, Orthohepevirus and Piscihepevirus. The Orthohepevirus genus has 4 species: A, B, C, and D. In humans, a majori...
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    Ravulizumab in Preemptive Living Donor Kidney Transplantation in Hereditary Atypical Hemolytic Uremic Syndrome
    Tilman Schmidt,Markus Goedel,Maida Mahmud,Lutz Fischer,Tobias B. Huber,Malte A. Kluger,Florian Grahammer
    Transplantation Direct（2022）
    Dear editor, we here report the first case of successful living donor kidney transplantation using complement inhibition by ravulizumab in a 33-y-old woman suffering from hereditary atypical hemolytic uremic syndrome (aHUS). Atypical HUS is the prototype for complement-mediated d...
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    Outcomes of SOT Recipients with COVID-19 in Different Eras of COVID-19 Therapeutics
    Afrah S. Sait,Teresa Po-Yu Chiang,Kieren A. Marr,Allan B. Massie,Willa Cochran,Pali Shah,Daniel C. Brennan,Alvin G. Thomas,Seema Mehta Steinke,Nitipong Permpalung,Shmuel Shoham,Christian Merlo,
    Transplantation Direct（2021）
    Background. Few reports have focused on newer coronavirus disease 2019 (COVID-19) therapies (remdesivir, dexamethasone, and convalescent plasma) in solid organ transplant recipients; concerns had been raised regarding possible adverse impact on allograft function or secondary inf...
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    Reduced Community-acquired Respiratory Virus Infection, but Not Non–virus Infection, in Lung Transplant Recipients During Government-mandated Public Health Measures to Reduce COVID-19 Transmission
    Brian C. Keller,Jianing Ma,Jing Peng,Verai Ramsammy
    TRANSPLANTATION DIRECT（2023）
    Background. Community-acquired respiratory viruses (CARVs) are an important cause of morbidity and mortality in lung transplant (LTx) recipients. Despite routine mask-wearing, LTx patients remain at a higher risk of CARV infection than the general population. In 2019, severe acut...
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    Rejection-associated Phenotype of De Novo Thrombotic Microangiopathy Represents a Risk for Premature Graft Loss
    Vojtech Petr,Petra Hruba,Marek Kollar,Karel Krejci,Roman Safranek,Sona Stepankova,Jarmila Dedochova,Jana Machova,Jakub Zieg,Janka Slatinska,Eva Pokorna,Ondrej Viklicky
    Transplantation Direct（2021）
    Background. Thrombotic microangiopathy (TMA) significantly affects kidney graft survival, but its pathophysiology remains poorly understood. Methods. In this multicenter, retrospective, case-control paired study designed to control for donor-associated risks, we assessed the reci...
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    Textbook Outcome As a Quality Metric in Liver Transplantation
    Austin D. Schenk,Jing L. Han,April J. Logan,Jeffrey M. Sneddon,Guy N. Brock,Timothy M. Pawlik,William K. Washburn
    Transplantation Direct（2022）
    Background. Quality in liver transplantation (LT) is currently measured using 1-y patient and graft survival. Because patient and graft survival rates now exceed 90%, more informative metrics are needed. Textbook outcomes (TOs) describe ideal patient outcomes after surgery. This ...
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    The Implications of the Shift Toward Donation after Circulatory Death in Australia
    Janske Reiling,Elizabeth Forrest,Kim R. Bridle,Laurence J. Britton,Nishreen Santrampurwala,Darrell H. G. Crawford,Cornelis H. C. Dejong,Jonathan Fawcett
    Transplantation direct（2017）
    Background. In recent years, an increasing number of donor livers are being declined for transplantation in Australia. The aim of this study was to evaluate the impact of donation after cardiac death and other factors associated with organ quality on liver utilization rates in Au...
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    Liver Transplantation for Recurrent Cholangitis from Von Meyenburg Complexes
    Nikhil Panda,Diane Brackett,Corey Eymard,Tatsuo Kawai,James Markmann,Camille N. Kotton,Karin Andersson,Heidi Yeh
    Transplantation Direct（2019）
    Von Meyenburg complexes, or multiple biliary hamartomas, are often asymptomatic lesions incidentally discovered during abdominal or hepatic imaging. The presentation of clinically significant Von Meyenburg complexes ranges from cholestasis and self-limited episodes of cholangitis...
    Cited6Views38
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    A New Look at XXYY Syndrome: Medical and Psychological Features
    Nicole Tartaglia,Shanlee Davis,Alison Hench, Sheela Nitnishakavi,Renee Beauregard,Ann Reynolds,Laura Fenton,Lindsey Albrecht,Judith Ross,Jeannie Visootsak,Robin Hansen,Randi Hagerman
    American Journal of Medical Genetics Part A（2008）
    XXYY syndrome occurs in approximately 1:18,000–1:40,000 males. Although the physical phenotype is similar to 47,XXY (tall stature, hypergonadotropic hypogonadism, and infertility), XXYY is associated with additional medical problems and more significant neurodevelopmental and psy...
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    Activin Biology after Lung Transplantation
    Glen P. Westall,Gregory I. Snell, Monika Loskot,Bronwyn Levvey,Robyn O'Hehir,Mark P. Hedger,David M. de Kretser
    Transplantation Direct（2017）
    BACKGROUND:Activins A and B, members of the TGF-β superfamily, are produced as part of the physiological response to tissue damage and the resulting proinflammatory response. Given that lung allograft reperfusion results in an inflammatory response, it is likely that the activins...
    Cited9Views23
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