Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

    • NPJ aging and mechanisms of disease Journal

    Papers
    Macrophages in Age-Related Chronic Inflammatory Diseases
    Yumiko Oishi,Ichiro Manabe
    npj Aging and Mechanisms of Disease（2016）
    Chronic inflammation is the common pathological basis for such age-associated diseases as cardiovascular disease, diabetes, cancer and Alzheimer's disease. A multitude of bodily changes occur with aging that contribute to the initiation and development of inflammation. In particu...
    Cited174Views0
    174
    0
    Download
    BibtexChatPaperRate
    Cytochrome B(5) Reductase and the Control of Lipid Metabolism and Healthspan
    Alejandro Martin-Montalvo,Yaning Sun,Alberto Diaz-Ruiz,Ahmed Ali,Vincent Gutierrez,Hector H Palacios,Jessica Curtis,Emilio Siendones,Julia Ariza,Gelareh A Abulwerdi,Xiaoping Sun,Annie X Wang,
    npj Aging and Mechanisms of Disease（2016）
    Cytochrome b(5) reductases (CYB5R) are required for the elongation and desaturation of fatty acids, cholesterol synthesis and monooxygenation of cytochrome P450 enzymes, all of which are associated with protection against metabolic disorders. However, the physiological role of CY...
    Cited51Views0
    51
    0
    Download
    BibtexChatPaperRate
    Lifespan-regulating Genes in C. Elegans
    Masaharu Uno,Eisuke Nishida
    npj Aging and Mechanisms of Disease（2016）
    The molecular mechanisms underlying the aging process have garnered much attention in recent decades because aging is the most significant risk factor for many chronic diseases such as type 2 diabetes and cancer. Until recently, the aging process was not considered to be an activ...
    Cited112Views0
    112
    0
    Download
    BibtexChatPaperRate
    Joint Association of Objective and Subjective Aging with Premature Mortality
    Minghao Kou, Hao Ma,Xuan Wang,Yoriko Heianza,Lu Qi
    npj Aging（2025）
    Objective and subjective aging indicators reflect diverse biological and psychosocial processes, yet their combined association with premature mortality remains underexplored. This study aimed to investigate the association between a multidomain framework of aging indicators and ...
    Cited0Views0
    0
    0
    Download
    BibtexChatPaperRate
    The Role of Klotho and Sirtuins in Sleep-Related Cardiovascular Diseases: a Review Study
    Farzaneh Rostamzadeh,Siyavash Joukar,Mahboobeh Yeganeh-Hajahmadi
    npj aging（2024）
    The prevalence of sleep disorders has been reported from 1.6% to 56.0%, worldwide. Sleep deprivation causes cardiovascular diseases (CVDs) including atherosclerosis, vascular aging, hypertension, heart dysfunction, reduced heart rate variability, and cardiac arrhythmia. Reduced t...
    Cited0Views0
    0
    0
    Download
    BibtexChatPaperRate
    A Decrease in NAD+ Contributes to the Loss of Osteoprogenitors and Bone Mass with Aging
    Ha-Neui Kim,Filipa Ponte,Aaron Warren,Rebecca Ring,Srividhya Iyer,Li Han,Maria Almeida
    International Journal of Cancer（2004）
    Age-related osteoporosis is caused by a deficit in osteoblasts, the cells that secrete bone matrix. The number of osteoblast progenitors also declines with age associated with increased markers of cell senescence. The forkhead box O (FoxO) transcription factors attenuate Wnt/β-ca...
    Cited118Views0
    118
    0
    Download
    BibtexChatPaperRate
    Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-handling Deficits in Alzheimer’s Disease Models
    Erez Eitan,Emmette R Hutchison,Krisztina Marosi, James Comotto,Maja Mustapic,Saket M Nigam,Caitlin Suire,Chinmoyee Maharana,Gregory A Jicha,Dong Liu,Vasiliki Machairaki,Kenneth W Witwer,
    NPJ aging and mechanisms of disease（2016）
    Alzheimer's Disease (AD) is an age-related neurodegenerative disorder in which aggregation-prone neurotoxic amyloid β-peptide (Aβ) accumulates in the brain. Extracellular vesicles (EVs) are small 50-150 nanometer membrane vesicles that have recently been implicated in the prion-l...
    Cited97Views0
    97
    0
    Download
    BibtexChatPaperRate
    Cytochrome B5 Protects Photoreceptors from Light Stress-Induced Lipid Peroxidation and Retinal Degeneration
    Xinping Chen,Hana Hall,Jeffrey P. Simpson,Walter D. Leon-Salas,Donald F. Ready,Vikki M. Weake
    npj Aging and Mechanisms of Disease（2017）
    Lipid peroxides are generated by oxidative stress in cells, and contribute to ageing and neurodegenerative disease. The eye is at special risk for lipid peroxidation because photoreceptors possess amplified sensory membranes rich in peroxidation-susceptible polyunsaturated fatty ...
    Cited36Views0
    36
    0
    Download
    BibtexChatPaperRate
    Blocking Negative Effects of Senescence in Human Skin Fibroblasts with a Plant Extract
    Ingo Lämmermann,Lucia Terlecki-Zaniewicz,Regina Weinmüllner,Markus Schosserer,Hanna Dellago,André Dargen de Matos Branco, Dominik Autheried,Benjamin Sevcnikar,Lisa Kleissl,Irina Berlin,Frédérique Morizot,Francois Lejeune,
    Journal of Investigative Dermatology（2017）
    There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life- and healthspan of mice. Senescent cells negatively affect their surrounding tissue by losing their cell specific func...
    Cited54Views0
    54
    0
    Download
    BibtexChatPaperRate
    Pyrroloquinoline Quinone (PQQ) Protects Mitochondrial Function of HEI-OC1 Cells under Premature Senescence
    Ying Gao,Teru Kamogashira,Chisato Fujimoto,Shinichi Iwasaki,Tatsuya Yamasoba
    npj Aging（2022）
    The aim of this study was to investigate the effects of pyrroloquinoline quinone (PQQ), an oxidoreductase cofactor, on the H2O2-induced premature senescence model in HEI-OC1 auditory cells and to elucidate its mechanism of action in vitro. Cells were treated with PQQ for 1 day be...
    Cited8Views0
    8
    0
    Download
    BibtexChatPaperRate
    Short-term Calorie Restriction Enhances DNA Repair by Non-Homologous End Joining in Mice
    Zhonghe Ke,Denis Firsanov,Brianna Spencer,Andrei Seluanov,Vera Gorbunova
    npj Aging and Mechanisms of Disease（2020）
    Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves repair of DNA double-stra...
    Cited13Views0
    13
    0
    Download
    BibtexChatPaperRate
    Adropin Correlates with Aging-Related Neuropathology in Humans and Improves Cognitive Function in Aging Mice
    Subhashis Banerjee,Sarbani Ghoshal,Clemence Girardet,Kelly M. DeMars,Changjun Yang,Michael L. Niehoff,Andrew D. Nguyen,Prerana Jayanth,Brittany A. Hoelscher,Fenglian Xu,William A. Banks,Kim M. Hansen,
    npj Aging and Mechanisms of Disease（2021）
    The neural functions of adropin, a secreted peptide highly expressed in the brain, have not been investigated. In humans, adropin is highly expressed in astrocytes and peaks during critical postnatal periods of brain development. Gene enrichment analysis of transcripts correlatin...
    Cited19Views0
    19
    0
    Download
    BibtexChatPaperRate
    Molecular Phenotyping of Oxidative Stress in Diabetes Mellitus with Point-of-care NMR System
    Weng Kung Peng,Lan Chen,Bernhard O. Boehm,Jongyoon Han,Tze Ping Loh
    npj Aging and Mechanisms of Disease（2020）
    Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new approach to rapidly manipulate and evaluate t...
    Cited24Views0
    24
    0
    Download
    BibtexChatPaperRate
    Activation of the NRF2 Pathway in Keap1-knockdown Mice Attenuates Progression of Age-Related Hearing Loss
    Tetsuya Oishi,Daisuke Matsumaru,Nao Ota,Hiroshi Kitamura, Tianxiang Zhang,Yohei Honkura,Yukio Katori,Hozumi Motohashi
    npj Aging and Mechanisms of Disease（2020）
    Age-related hearing loss (AHL) is a progressive sensorineural hearing loss in elderly people. Although no prevention or treatments have been established for AHL, recent studies have demonstrated that oxidative stress is closely related to pathogenesis of AHL, suggesting that supp...
    Cited17Views0
    17
    0
    Download
    BibtexChatPaperRate
    Granzyme B Mediates Impaired Healing of Pressure Injuries in Aged Skin
    Christopher T. Turner,Juliana Bolsoni,Matthew R. Zeglinski,Hongyan Zhao,Tatjana Ponomarev,Katlyn Richardson,Sho Hiroyasu, Erin Schmid,Anthony Papp,David J. Granville
    npj Aging and Mechanisms of Disease（2021）
    Pressure injuries (PIs), also known as bedsores or pressure ulcers, are a major cause of death and morbidity in the elderly. The serine protease, Granzyme B (GzmB), contributes to skin aging and impaired wound healing. Aging is a major risk factor for PIs; thus, the role of GzmB ...
    Cited10Views0
    10
    0
    Download
    BibtexChatPaperRate
    Spontaneous P53 Activation in Middle-Aged C57BL/6 Mice Mitigates the Lifespan-Extending Adaptive Response Induced by Low-Dose Ionizing Radiation
    Masaoki Kohzaki,Keiji Suzuki,Akira Ootsuyama,Ryuji Okazaki
    NPJ AGING（2023）
    Understanding the biological effects of low-dose (<100 mGy) ionizing radiation (LDR) is technically challenging. We investigated age-dependent LDR effects using adaptive response experiments in young (7-to 12-week-old) and middle-aged (40-to 62-week-old) C57BL/6 mice. Compared wi...
    Cited0Views0
    0
    0
    Download
    BibtexChatPaperRate
    NQO1 Protects Obese Mice Through Improvements in Glucose and Lipid Metabolism
    Andrea Di Francesco,Youngshim Choi,Michel Bernier,Yingchun Zhang,Alberto Diaz-Ruiz,Miguel A. Aon,Krystle Kalafut,Margaux R. Ehrlich,Kelsey Murt,Ahmed Ali,Kevin J. Pearson, Sophie Levan,
    npj Aging and Mechanisms of Disease（2020）
    Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred p...
    Cited20Views0
    20
    0
    Download
    BibtexChatPaperRate
    Identification of Transcription Factors That Promote the Differentiation of Human Pluripotent Stem Cells into Lacrimal Gland Epithelium-Like Cells
    Masatoshi Hirayama,Shigeru B.H. Ko,Tetsuya Kawakita,Tomohiko Akiyama,Sravan K. Goparaju,Atsumi Soma,Yuhki Nakatake,Miki Sakota,Nana Chikazawa-Nohtomi,Shigeto Shimmura,Kazuo Tsubota,Minoru S.H. Ko
    npj Aging and Mechanisms of Disease（2017）
    Dry eye disease is the most prevalent pathological condition in aging eyes. One potential therapeutic strategy is the transplantation of lacrimal glands, generated in vitro from pluripotent stem cells such as human embryonic stem cells, into patients. One of the preceding require...
    Cited26Views0
    26
    0
    Download
    BibtexChatPaperRate
    Both Overlapping and Independent Mechanisms Determine How Diet and Insulin-Ligand Knockouts Extend Lifespan of Drosophila Melanogaster
    Jelle Zandveld,Joost van den Heuvel, Bastiaan J. Zwaan,Matthew D.W. Piper
    npj Aging and Mechanisms of Disease（2017）
    Lifespan in many organisms, including Drosophila melanogaster, can be increased by reduced insulin-IGF-like signaling (IIS) or by changes in diet. Most studies testing whether IIS is involved in diet-mediated lifespan extension employ only a few diets, but recent data shows that ...
    Cited8Views0
    8
    0
    Download
    BibtexChatPaperRate