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Astrocyte-targeted Gene Delivery of Interleukin 2 Specifically Increases Brain-Resident Regulatory T Cell Numbers and Protects Against Pathological Neuroinflammation

Lidia Yshii,Emanuela Pasciuto,Pascal Bielefeld,Loriana Mascali,Pierre Lemaitre,Marika Marino,James Dooley,Lubna Kouser,Stijn Verschoren,Vasiliki Lagou,Hannelore Kemps,Pascal Gervois,Antina de Boer,Oliver T. Burton,Jérôme Wahis,Jens Verhaert,Samar H. K. Tareen,Carlos P. Roca,Kailash Singh,Carly E. Whyte,Axelle Kerstens,Zsuzsanna Callaerts-Vegh,Suresh Poovathingal,Teresa Prezzemolo,Keimpe Wierda,Amy Dashwood,Junhua Xie,Elien Van Wonterghem,Eline Creemers,Meryem Aloulou,Willy Gsell,Oihane Abiega,Sebastian Munck,Roosmarijn E. Vandenbroucke,Annelies Bronckaers,Robin Lemmens,Bart De Strooper,Ludo Van Den Bosch,Uwe Himmelreich,Carlos P. Fitzsimons,Matthew G. Holt,Adrian Liston

Nature Immunology（2022）

Cited 59|Views45
Key words
Immunotherapy,Interleukins,Neuroimmunology,Regulatory T cells,Biomedicine,general,Immunology,Infectious Diseases
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