Abstract P034: Prevent Cancer-Greenville: Identifying and Influencing Cancer Risk

Abstract Purpose: Prevent Cancer - Greenville started in 2018 and provides study participants the opportunity to have their risk of developing cancer stratified into a personalized plan of screening and behavior modification as well as contribute to longitudinal cancer prevention research. Prevent Cancer - Greenville’s dual objectives include a participant educational focus based on individual risks as well as a long-term research objective of correlation of lifestyle and environmental influences on an individual’s molecular constitution and for those affected, the development of a cancer. Methods: Volunteer participants are accrued through open enrollment which is promoted through Prisma News, printed and online news articles, community events and a listing on the National Institute of Health clinicaltrials.gov website. Participants must be at least 18 years of age and must speak English to enroll. Enrollees participate in a yearly risk assessment, including diet, exercise, body composition using bioimpedance spectroscopy, and individual risk factors, with the data banked in a longitudinal manner. At each yearly visit, blood, urine, and buccal swab specimens are collected and stored along with participant’s lifestyle habits, body composition, and medical history as discrete data points. The potential to store thousands of participants’ specimens yearly for a decade or more creates an opportunity to retrospectively identify the likely multiple and sequential molecular events leading to the development of cancer. In short, patients eventually developing a malignancy will have a biological repository of DNA, RNA, and proteins that can potentially be deciphered as “steppingstones” leading to their illness. These molecular signatures will open the prospect of predicting cancer event pathways before clinical cancer develops, helping to correlate the epigenetic hallmarks of cancer development (nutrition, exercise, body fat content, microbiome). Results: Our team analyzed the current data collection for the 848 total participants accrued. The participants are 77.2% female and 22.8% male. Race is made up of 91.6% Caucasian, 6.3% African American, 1.3% Asian, and 0.7% Other. Ethnicity includes 2.6% Hispanic or Latino and 97.4% Non-Hispanic or Latino. A total of 11 participants have developed cancer since enrollment in the study. A total of 1600 buccal aliquots, 4,496 blood aliquots, and 888 urine aliquots are currently stored in the biorepository. Germline testing provided by a genetic counselor outside of the study identified 107 participants with pathogenic gene variants. Conclusion: The sequential annual visits will allow future molecular mapping and support strategies for early identification of malignancy and prevention of clinical disease through targeted interventions. To date, improving diversity has been challenging despite continued efforts. Citation Format: Larry Gluck, Armand DeSollar, Matthew Hudson, LeAnn Perkins, Julia Yates, Susan Webb, Gina Franco. Prevent Cancer-Greenville: identifying and influencing cancer risk. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr P034.