Factores De Riesgo Para Seropositividad Para Herpes Virus Humano 8 En Pacientes Insuficientes Renales Crónicos En Lista De Espera Para Trasplante Y En Receptores De Trasplante Renal

The prevalence of human herpes virus-8 antibodies has a great geographic variability in the general population and in pre- and post-kidney transplant recipients, and is associated with the development of Kaposi's sarcoma. In Mexico, hu- man herpes virus-8 seroprevalence in 307 blood donors was 0.65%. Aim: To investigate: 1) human herpes virus-8 serop- revalence, and 2) associated risk factors for seropositivity, in a) 156 chronic renal failure patients (pts) randomly selected from a waiting list for cadaveric transplantation, and b) 118 kidney transplant recipients with functioning grafts at diverse post-Kidney transplant follow up. Methods: Demo- graphic data were obtained for kidney transplant recipients from clinical files and by a self-administered questionnaire for sexual practices; in chronic renal failure pts, data were obtained by direct interview. Serum samples from all pts were tested for IgG antibodies using an ELISA commercial kit. Data analyzed: chronic renal failure group: mean age 36 ± 13 years, 50% male, overall mean time on dialysis 43 ± 47 mos (20.5% hemodialysis, 56% CAPD, 18.6% both, 5 none), blood transfusion history (BT) 78%, previous kidney transplant 9%. Kidney transplant recipients group: mean age 30 ± 11 years, 55% male, mean time post-kidney transplant follow up 111 ± 70 mos, pre-kidney transplant overall time on dialysis 22 ± 21.8 mos (37% hemodialysis, 35.6% CAPD, 23% both, 4% none), blood transfusion 79%, triple drug im- munosuppressive therapy 76%. Results: human herpes vi-