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Deep Mining of the Human Antibody Repertoire Identifies Frequent and Immunogenetically Diverse CDRH3 Topologies Targetable by Vaccination

Rumi Habib, Shahlo O. Solieva, Zi Jie Lin, Sukanya Ghosh, Kelly Bayruns, Maya Singh, Colby J. Agostino,Nicholas J. Tursi, Kirsten J. Sowers, Jinwei Huang,Ryan S. Roark,Mansi Purwar,Younghoon Park,Kasirajan Ayyanathan, Hui Li, John W. Carey, Amber Kim, Joyce Park, Madison E. McCanna,Ashwin N. Skelly,Neethu Chokkalingam, Sinja Kriete, Nicholas Shupin, Alana Huynh,Susanne Walker, Niklas Laenger,Jianqiu Du,Jiayan Cui,Beatrice H. Hahn,Ami Patel,Amelia Escolano,Peter D. Kwong,Lawrence Shapiro,Gregory R. Bowman,George M. Shaw,David B. Weiner,Jesper Pallesen,Daniel W. Kulp

biorxiv(2024)

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